PDF DatasheetHuman Prolactin / PRL Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Prolactin / PRL based upon sequence from: Human
Host: QDX59 protein expressed in Human.
Tag: Native
Recommended Applications: Immunogen, Protein Standard, Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QDX59.
Purity: Greater than 95% as verified by SDS-PAGE.
Concentration of Human Prolactin / PRL Protein:
Endotoxin Levels: Untested
Buffer: 20mM Tris-Hcl, 0.5M NaCl, pH 8.0
Storage Conditions: Upon receipt aliquot and store at -20C or -80C. Avoid repeated freeze.
| Recombinant Recombinant Human Prolactin / PRL Protein – Antigen Standard General Information | |
|---|---|
| Alternate Names | |
| Prolactin; PRL; GHA1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PRL |
| Entrez Gene ID | 5617 |
| Ensemble Gene ID | ENSG00000172179 |
| RefSeq Protein Accession(s) | NP_000939.1 |
| RefSeq mRNA Accession(s) | NM_000948.5, NM_001163558.2 |
| UniProt ID(s) | P01236 |
| UniGene ID(s) | Hs.1905 |
| HGNC ID(s) | HGNC:9445 |
| COSMIC ID Link(s) | PRL |
| KEGG Gene ID(s) | hsa:5617 |
| PharmGKB ID(s) | PA33790 |
| General Description of Recombinant Recombinant Human Prolactin / PRL Protein – Antigen Standard. | |
| Prolactin (PRL), also known as luteotropic hormone or luteotropin, is an hormone formed by a 199aa mature chain consisting of three disulfide bonds. Prolactin is secreted from the pituitary gland in response to eating, mating, estrogen treatment, ovulation, and nursing. Prolactin is secreted in a pulsatile manner between these events. Prolactin also plays an essential role in metabolism, regulation of the immune system, and pancreatic development. In normal individuals,prolactin concentrations increase in response to physiologic stimuli such as sleep, stress, exercise, sexual intercourse, and hypoglycemia, and are also elevated during pregnancy, lactation, postpartum, and in the newborn infant. Though, prolactin levels are found elevated ven in non-pregnant and non-breastfeeding woman, or in male. The most common cause is a prolactinoma, a usually benign (not cancerous) prolactin-producing tumor of the pituitary gland. The prolactin test may be used as part of a work-up for irregular menstrual periods, fertility problems, some types of thyroid or adrenal gland dysfunction, anorexia, and polycystic ovarian syndrome. Prolactin tests were also used to diagnose, or monitor treatment of prolactinoma. Symptoms of a prolactinoma include headaches, vision problems (if tumor growth is causing pressure on an the optic nerve), and galactorrhea (milk production outside pregnancy or breastfeeding, or in a male). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). The product is guaranteed for a period of two years, if stored under the specified conditions.
There are no reviews yet.