PDF DatasheetHuman Protein cereblon Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein cereblon based upon sequence from: Human
Host: QP10011 protein expressed in Invitro-E.coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) Protein cereblon, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10011.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu442
Amino Acid Sequence: MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS ALLPTIPDTE DEISPDKVIL CL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein cereblon Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein cereblon Protein General Information | |
|---|---|
| Alternate Names | |
| MRT2; MRT2A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Crbn |
| Entrez Gene ID | 51185 |
| Ensemble Gene ID | ENSG00000113851 |
| RefSeq Protein Accession(s) | NP_001166953.1 |
| RefSeq mRNA Accession(s) | NM_001173482.1, NM_016302.3 |
| UniProt ID(s) | Q96SW2 |
| UniGene ID(s) | Hs.18925 |
| HGNC ID(s) | HGNC:30185 |
| COSMIC ID Link(s) | Crbn |
| KEGG Gene ID(s) | hsa:51185 |
| PharmGKB ID(s) | PA134926851 |
| General Description of Recombinant Human Protein cereblon Protein. | |
| Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3 | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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