PDF DatasheetMouse Protein cereblon Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein cereblon based upon sequence from Mouse
Host: QP9830 protein expressed in Yeast.
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Protein cereblon, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9830.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu445
Amino Acid Sequence: MAGEGDQQDA AHNMGNHLPL LPADSEDEDD EIEMEVEDQD SKEARKPNII NFDTSLPTSH TYLGADMEEF HGRTLHDDDS CQVIPVLPEV LMILIPGQTL PLQLSHPQEV SMVRNLIQKD RTFAVLAYSN VQEREAQFGT TAEIYAYREE QEFGIEVVKV KAIGRQRFKV LELRTQSDGI QQAKVQILPE CVLPSTMSAV QLESLNKCQV FPSKPISWED QYSCKWWQKY QKRKFHCANL TSWPRWLYSL YDAETLMDRI KKQLREWDEN LKDDSLPENP IDFSYRVAAC LPIDDVLRIQ LLKIGSAIQR LRCELDIMNK CTSLCCKQCQ ETEITTKNEI FSLSLCGPMA AYVNPHGYVH ETLTVYKASN LNLIGRPSTV HSWFPGYAWT IAQCKICASH IGWKFTATKK DMSPQKFWGL TRSALLPTIP ETEDEISPDK VILCL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Protein cereblon Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Protein cereblon Protein General Information | |
|---|---|
| Alternate Names | |
| AF229032; 2900045O07Rik; 2610203G15Rik; piL; AW108261 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Crbn |
| Entrez Gene ID | 58799 |
| Ensemble Gene ID | ENSMUSG00000005362 |
| RefSeq Protein Accession(s) | NP_067424.2 |
| RefSeq mRNA Accession(s) | NM_021449.3, NM_175357.3 |
| UniProt ID(s) | Q8C7D2 |
| UniGene ID(s) | Mm.290085 |
| COSMIC ID Link(s) | Crbn |
| KEGG Gene ID(s) | mmu:58799 |
| General Description of Recombinant Mouse Protein cereblon Protein. | |
| Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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