PDF DatasheetHuman Thioredoxin-interacting protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Thioredoxin-interacting protein based upon sequence from: Human
Host: QP10023 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) Thioredoxin-interacting protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10023.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln391
Amino Acid Sequence: MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG VAKVLWMQGS QQCKQTSEYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK FGFELPQGPL GTSFKGKYGC VDYWVKAFLD RPSQPTQETK KNFEVVDLVD VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV SARIDRKGFC EGDEISIHAD FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN HIISGTCASW RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDVIPE DHRLESPTTP LLDDMDGSQD SPIFMYAPEF KFMPPPTYTE VDPCILNNNV Q
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Thioredoxin-interacting protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Thioredoxin-interacting protein Protein General Information | |
|---|---|
| Alternate Names | |
| THIF; ARRDC6; HHCPA78; EST01027; VDUP1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Txnip |
| Entrez Gene ID | 10628 |
| Ensemble Gene ID | ENSG00000265972 |
| RefSeq Protein Accession(s) | NP_001300901.1 |
| RefSeq mRNA Accession(s) | NM_001313972.1, NM_006472.5 |
| UniProt ID(s) | Q9H3M7 |
| UniGene ID(s) | Hs.533977 |
| HGNC ID(s) | HGNC:16952 |
| COSMIC ID Link(s) | Txnip |
| KEGG Gene ID(s) | hsa:10628 |
| PharmGKB ID(s) | PA38194 |
| General Description of Recombinant Human Thioredoxin-interacting protein Protein. | |
| May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.