PDF DatasheetMouse Thioredoxin-interacting protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Thioredoxin-interacting protein based upon sequence from Mouse
Host: QP9833 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Thioredoxin-interacting protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9833.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln397
Amino Acid Sequence: MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG VAKVLWMQGS QQCKQTLDYL RYEDTLLLEE QPTAGENEMV IMRPGNKYEY KFGFELPQGP LGTSFKGKYG CVDYWVKAFL DRPSQPTQEA KKNFEVMDLV DVNTPDLMAP VSAKKEKKVS CMFIPDGRVS VSARIDRKGF CEGDDISIHA DFENTCSRIV VPKAAIVARH TYLANGQTKV FTQKLSSVRG NHIISGTCAS WRGKSLRVQK IRPSILGCNI LKVEYSLLIY VSVPGSKKVI LDLPLVIGSR SGLSSRTSSM ASRTSSEMSW IDLNIPDTPE APPCYMDIIP EDHRLESPTT PLLDDVDDSQ DSPIFMYAPE FQFMPPPTYT EVDPCVLNNN NNNNNVQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Thioredoxin-interacting protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Thioredoxin-interacting protein Protein General Information | |
|---|---|
| Alternate Names | |
| VDUP1; THIF; AA682105; 1200008J08Rik; Hyplip1; Tbp-2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Txnip |
| Entrez Gene ID | 56338 |
| Ensemble Gene ID | ENSMUSG00000038393 |
| RefSeq Protein Accession(s) | NP_001009935.1 |
| RefSeq mRNA Accession(s) | NM_001009935.2, NM_023719.2 |
| UniProt ID(s) | Q8BG60 |
| UniGene ID(s) | Mm.410189 |
| COSMIC ID Link(s) | Txnip |
| KEGG Gene ID(s) | mmu:56338 |
| General Description of Recombinant Mouse Thioredoxin-interacting protein Protein. | |
| May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) . Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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