PDF DatasheetHuman NAP-2 / PPBP / CXCL7 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant NAP-2 / PPBP / CXCL7 based upon sequence from: Human
Host: QP10212 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human NAP-2 / PPBP / CXCL7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10212.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human NAP-2 / PPBP / CXCL7 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NAP-2 / PPBP / CXCL7 Protein General Information | |
|---|---|
| Alternate Names | |
| NAP-2; PPBP; CXCL7; Cxcl7; NAP-2; TGB1; 2400003M24Rik; CTAP3; LDGF; AI854500; b-TG1; LA-PF4; MDGF; NAP-2-L1; Scyb7; THBGB1; beta-TG; TGB; CTAPIII | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PPBP |
| Entrez Gene ID | 5473 |
| Ensemble Gene ID | ENSG00000163736 |
| RefSeq Protein Accession(s) | NP_002695.1 |
| RefSeq mRNA Accession(s) | NM_002704.3 |
| UniProt ID(s) | P02775 |
| UniGene ID(s) | Hs.2164 |
| HGNC ID(s) | HGNC:9240 |
| COSMIC ID Link(s) | PPBP |
| KEGG Gene ID(s) | hsa:5473 |
| PharmGKB ID(s) | PA33561 |
| General Description of Recombinant Human NAP-2 / PPBP / CXCL7 Protein. | |
| LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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