PDF DatasheetMouse CCL5 / RANTES Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant CCL5 / RANTES based upon sequence from: Mouse
Host: QP10265 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Mouse CCL5 / RANTES, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10265.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human T lymphocytes is in a concentration range of 1.0-10 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Mouse CCL5 / RANTES Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse CCL5 / RANTES Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL5 |
| Entrez Gene ID | 20304 |
| Ensemble Gene ID | ENSMUSG00000035042 |
| RefSeq Protein Accession(s) | NP_038681.2 |
| RefSeq mRNA Accession(s) | NM_013653.3 |
| UniProt ID(s) | P30882 |
| KEGG Gene ID(s) | mmu:20304 |
| General Description of Recombinant Mouse CCL5 / RANTES Protein. | |
| Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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