PDF DatasheetMouse MIP-3 beta / CCL19 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant MIP-3 beta / CCL19 based upon sequence from: Mouse
Host: QP10273 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Mouse MIP-3 beta / CCL19, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10273.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human mature dendritic cells is in a concentration range of 10-100 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Mouse MIP-3 beta / CCL19 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse MIP-3 beta / CCL19 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL19 |
| Entrez Gene ID | 100039053 |
| Ensemble Gene ID | ENSMUSG00000071005 |
| RefSeq Protein Accession(s) | NP_036018.1 |
| RefSeq mRNA Accession(s) | NM_011888.2, XM_001472168.6 |
| UniProt ID(s) | O70460 |
| COSMIC ID Link(s) | CCL19 |
| KEGG Gene ID(s) | mmu:100039053 |
| General Description of Recombinant Mouse MIP-3 beta / CCL19 Protein. | |
| Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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