PDF DatasheetHuman IL-1RA / IL1RN Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-1RA / IL1RN based upon sequence from: Human
Host: QP10308 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL-1RA / IL1RN, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10308.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by inhibiting IL-1alpha- dependent proliferation of murine D10S cells is less than 40 ng/ml, corresponding to a specific activity of > 2.5 × 104 IU/mg in the presence of 50 pg/ml rHuIL-1alpha.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE
Purity: Greater than 96% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL-1RA / IL1RN Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL-1RA / IL1RN Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL1RN |
| Entrez Gene ID | 3557 |
| Ensemble Gene ID | ENSG00000136689 |
| RefSeq Protein Accession(s) | NP_000568.1 |
| RefSeq mRNA Accession(s) | NM_000577.4, NM_001318914.1, NM_173841.2, NM_173842.2, NM_173843.2, XM_005263661.4, XM_011511121.1 |
| UniProt ID(s) | P18510 |
| UniGene ID(s) | Hs.81134 |
| HGNC ID(s) | HGNC:6000 |
| COSMIC ID Link(s) | IL1RN |
| KEGG Gene ID(s) | hsa:3557 |
| PharmGKB ID(s) | PA29816 |
| General Description of Recombinant Human IL-1RA / IL1RN Protein. | |
| Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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