PDF DatasheetMouse IL-1RA / IL1RN Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-1RA / IL1RN based upon sequence from: Mouse
Host: QP10450 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Mouse IL-1RA / IL1RN, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10450.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by inhibiting IL-1alpha- dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg in the presence of 50 pg/ml rHuIL-1alpha.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: RPSGKRPCKM QAFRIWDTNQ KTFYLRNNQL IAGYLQGPNI KLEEKIDMVP IDLHSVFLGI HGGKLCLSCA KSGDDIKLQL EEVNITDLSK NKEEDKRFTF IRSEKGPTTS FESAACPGWF LCTTLEADRP VSLTNTPEEP LIVTKFYFQE DQ
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Mouse IL-1RA / IL1RN Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse IL-1RA / IL1RN Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Il1rn |
| Entrez Gene ID | 16181 |
| Ensemble Gene ID | ENSMUSG00000026981 |
| RefSeq Protein Accession(s) | NP_001034790.1 |
| RefSeq mRNA Accession(s) | NM_001039701.3, NM_031167.5 |
| UniProt ID(s) | P25085 |
| COSMIC ID Link(s) | Il1rn |
| KEGG Gene ID(s) | mmu:16181 |
| General Description of Recombinant Mouse IL-1RA / IL1RN Protein. | |
| Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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