PDF DatasheetHuman IL-8 / CXCL8 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-8 / CXCL8 based upon sequence from: Human
Host: QP10315 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL-8 / CXCL8, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10315.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 ×105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL-8 / CXCL8 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL-8 / CXCL8 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-8; CXCL8; GCP-1; MDNCF; NAP1; GCP1; IL8; NAF; MONAP; LECT; LYNAP; NAP-1; LUCT | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CXCL8 |
| Entrez Gene ID | 3576 |
| Ensemble Gene ID | ENSG00000169429 |
| RefSeq Protein Accession(s) | NP_000575.1 |
| RefSeq mRNA Accession(s) | NM_000584.3 |
| UniProt ID(s) | P10145 |
| UniGene ID(s) | Hs.624 |
| HGNC ID(s) | HGNC:6025 |
| KEGG Gene ID(s) | hsa:3576 |
| PharmGKB ID(s) | PA29841 |
| General Description of Recombinant Human IL-8 / CXCL8 Protein. | |
| IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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