PDF DatasheetHuman IL-31 / IL31 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-31 / IL31 based upon sequence from: Human
Host: QP10328 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL-31 / IL31, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10328.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The specific activity is determined by inducing STAT3 activation using human U-87 MG cells. 5 ng/mL of rHuIL-31 can effectively induce STAT3 activation.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL-31 / IL31 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL-31 / IL31 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-31; IL31; 1700013B14Rik | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL31 |
| Entrez Gene ID | 386653 |
| Ensemble Gene ID | ENSG00000204671 |
| RefSeq Protein Accession(s) | NP_001014358.1 |
| RefSeq mRNA Accession(s) | NM_001014336.1 |
| UniProt ID(s) | Q6EBC2 |
| HGNC ID(s) | HGNC:19372 |
| COSMIC ID Link(s) | IL31 |
| KEGG Gene ID(s) | hsa:386653 |
| PharmGKB ID(s) | PA134957950 |
| General Description of Recombinant Human IL-31 / IL31 Protein. | |
| Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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