Human IL33 / Interleukin-33 / NF-HEV Protein Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL33 / Interleukin-33 / NF-HEV Protein based upon sequence from: Human
Host: QP10329 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL33 / Interleukin-33 / NF-HEV Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10329.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.05 ng/ml, corresponding to a specific activity of > 2.0 × 107 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL33 / Interleukin-33 / NF-HEV Protein Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2um filtered 20 mM PBS, 150 mM NaCl, 1mM EDTA, pH7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
Recombinant Human IL33 / Interleukin-33 / NF-HEV Protein Protein General Information | |
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Alternate Names | |
IL33; Interleukin-33; NF-HEV Protein; NF-HEV; C9orf26; DVS27; IL1F11; NFEHEV | |
Curated Database and Bioinformatic Data | |
Gene Symbol | IL33 |
Entrez Gene ID | 90865 |
Ensemble Gene ID | ENSG00000137033 |
RefSeq Protein Accession(s) | NP_001186569.1 |
RefSeq mRNA Accession(s) | NM_001199640.1, NM_001199641.1, NM_001314044.1, NM_001314045.1, NM_001314046.1, NM_001314047.1, NM_001314048.1, NM_033439.3 |
UniProt ID(s) | O95760 |
UniGene ID(s) | Hs.731660 |
HGNC ID(s) | HGNC:16028 |
COSMIC ID Link(s) | IL33 |
KEGG Gene ID(s) | hsa:90865 |
PharmGKB ID(s) | PA162392005 |
General Description of Recombinant Human IL33 / Interleukin-33 / NF-HEV Protein Protein. | |
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an “alarmin”, that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). ; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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