PDF DatasheetMouse IL33 / Interleukin-33 / NF-HEV Protein Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL33 / Interleukin-33 / NF-HEV Protein based upon sequence from: Mouse
Host: QP10464 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Mouse IL33 / Interleukin-33 / NF-HEV Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10464.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 106 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI
Purity: Greater than 98% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Mouse IL33 / Interleukin-33 / NF-HEV Protein Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, and 1 mM EDTA, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse IL33 / Interleukin-33 / NF-HEV Protein Protein General Information | |
|---|---|
| Alternate Names | |
| IL33; Interleukin-33; NF-HEV Protein; NF-HEV; C9orf26; DVS27; IL1F11; NFEHEV | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL33 |
| Entrez Gene ID | 77125 |
| Ensemble Gene ID | ENSMUSG00000024810 |
| RefSeq Protein Accession(s) | NP_001158196.1 |
| RefSeq mRNA Accession(s) | NM_001164724.1, NM_133775.2, XM_006527463.3, XM_011247399.2 |
| UniProt ID(s) | Q8BVZ5 |
| UniGene ID(s) | Mm.182359 |
| COSMIC ID Link(s) | IL33 |
| KEGG Gene ID(s) | mmu:77125 |
| General Description of Recombinant Mouse IL33 / Interleukin-33 / NF-HEV Protein Protein. | |
| Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an “alarmin”, that amplifies immune responses during tissue injury.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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