PDF DatasheetHuman IL1F6 / IL36 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL1F6 / IL36 based upon sequence from: Human
Host: QP10330 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL1F6 / IL36, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10330.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The specific activity determined by its ability in a functional ELISA. Immobilized rHuIL-36alpha at 1 ug/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 ug/mL.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL1F6 / IL36 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 2 × PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL1F6 / IL36 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Il36a |
| Entrez Gene ID | 27179 |
| Ensemble Gene ID | ENSG00000136694 |
| RefSeq Protein Accession(s) | NP_055255.1 |
| RefSeq mRNA Accession(s) | NM_014440.2, XM_005263639.2, XM_011510965.1, XM_017003806.1 |
| UniProt ID(s) | Q9UHA7 |
| UniGene ID(s) | Hs.278910 |
| HGNC ID(s) | HGNC:15562 |
| COSMIC ID Link(s) | Il36a |
| KEGG Gene ID(s) | hsa:27179 |
| PharmGKB ID(s) | PA38389 |
| General Description of Recombinant Human IL1F6 / IL36 Protein. | |
| Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T cell proliferation. May play a role in proinflammatory effects in the lung. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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