PDF DatasheetHuman IGF1 Isoform 2 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IGF1 Isoform 2 based upon sequence from: Human
Host: QP10335 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IGF1 Isoform 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10335.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by the stimulation of protein synthesis using rat L6 myoblasts is less than 10 ng/ml, corresponding to a specific activity of > 1.0 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Purity: Greater than 95% as determined by SDSPAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IGF1 Isoform 2 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 m filtered PBS, pH 7.0, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IGF1 Isoform 2 Protein General Information | |
|---|---|
| Alternate Names | |
| IGF1; IGF-I; IGF-I; MGF; IGFI | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IGF1 |
| Entrez Gene ID | 3479 |
| Ensemble Gene ID | ENSG00000017427 |
| RefSeq Protein Accession(s) | NP_000609.1 |
| RefSeq mRNA Accession(s) | NM_000618.4, NM_001111284.1, NM_001111285.2 |
| UniProt ID(s) | P05019 |
| UniGene ID(s) | Hs.160562 |
| HGNC ID(s) | HGNC:5464 |
| COSMIC ID Link(s) | IGF1 |
| KEGG Gene ID(s) | hsa:3479 |
| PharmGKB ID(s) | PA29697 |
| General Description of Recombinant Human IGF1 Isoform 2 Protein. | |
| The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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