PDF DatasheetHuman IL1F5 / IL36RN Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL1F5 / IL36RN based upon sequence from: Human
Host: QP10343 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL1F5 / IL36RN, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10343.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by inhibiting IL-36 beta induced IL-8 secretion by human preadipocytes is less than 1.0 ug/ml, corresponding to a specific activity of > 1000 IU/mg in the presence of 20 ng/ml of recombinant human IL-36 beta.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAGKVIKGEE ISVVPNRWLD ASLSPVILGV QGGSQCLSCG VGQEPTLTLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTVPEADQPV RLTQLPENGG WNAPITDFYF QQCD
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL1F5 / IL36RN Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL1F5 / IL36RN Protein General Information | |
|---|---|
| Alternate Names | |
| IL1F5; IL36RN; IL1HY1; FIL1(DELTA); PSORP; IL1RP3; IL1L1; IL36RA; FIL1; IL-36Ra; PSORS14; FIL1D; IL1F5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL36RN |
| Entrez Gene ID | 26525 |
| Ensemble Gene ID | ENSG00000136695 |
| RefSeq Protein Accession(s) | NP_036407.1 |
| RefSeq mRNA Accession(s) | NM_012275.2, NM_173170.1 |
| UniProt ID(s) | Q9UBH0 |
| UniGene ID(s) | Hs.516301 |
| HGNC ID(s) | HGNC:15561 |
| COSMIC ID Link(s) | IL36RN |
| KEGG Gene ID(s) | hsa:26525 |
| PharmGKB ID(s) | PA38388 |
| General Description of Recombinant Human IL1F5 / IL36RN Protein. | |
| Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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