PDF DatasheetMouse IL1F5 / IL36RN Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL1F5 / IL36RN based upon sequence from: Mouse
Host: QP10438 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Mouse IL1F5 / IL36RN, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10438.
Bioactivity Data: Measured by its ability to inhibit IL-36gamma induced IL-6 production by human PBMCs.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Mouse IL1F5 / IL36RN Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse IL1F5 / IL36RN Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL36RN |
| Entrez Gene ID | 54450 |
| Ensemble Gene ID | ENSMUSG00000026983 |
| RefSeq Protein Accession(s) | NP_001139559.1 |
| RefSeq mRNA Accession(s) | NM_001146087.1, NM_001146088.1, NM_019451.2 |
| UniProt ID(s) | Q9QYY1 |
| COSMIC ID Link(s) | IL36RN |
| KEGG Gene ID(s) | mmu:54450 |
| General Description of Recombinant Mouse IL1F5 / IL36RN Protein. | |
| Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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