PDF DatasheetHuman BLyS / TNFSF13B / BAFF Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant BLyS / TNFSF13B / BAFF based upon sequence from: Human
Host: QP10357 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human BLyS / TNFSF13B / BAFF, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10357.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a mouse splenocyte survival assay is 0.5-2 ug/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human BLyS / TNFSF13B / BAFF Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH7.4, with 0.02 % Tween-20, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human BLyS / TNFSF13B / BAFF Protein General Information | |
|---|---|
| Alternate Names | |
| BLyS; TNFSF13B; BAFF; TNFSF20; DTL; THANK; ZTNF4; BLYS; CD257; TALL1; TNLG7A; BAFF; TALL-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFSF13B |
| Entrez Gene ID | 10673 |
| Ensemble Gene ID | ENSG00000102524 |
| RefSeq Protein Accession(s) | NP_001139117.1 |
| RefSeq mRNA Accession(s) | NM_001145645.2, NM_006573.4 |
| UniProt ID(s) | Q9Y275 |
| UniGene ID(s) | Hs.525157 |
| HGNC ID(s) | HGNC:11929 |
| COSMIC ID Link(s) | TNFSF13B |
| KEGG Gene ID(s) | hsa:10673 |
| PharmGKB ID(s) | PA434 |
| General Description of Recombinant Human BLyS / TNFSF13B / BAFF Protein. | |
| Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. ; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. ; Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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