PDF DatasheetHuman Oncostatin M / OSM Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Oncostatin M / OSM based upon sequence from: Human
Host: QP10363 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Oncostatin M / OSM, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10363.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRRT RPSRKGKRLM TRGQLPR
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Oncostatin M / OSM Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Oncostatin M / OSM Protein General Information | |
|---|---|
| Alternate Names | |
| Oncostatin M; OSM; OncoM | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | OSM |
| Entrez Gene ID | 5008 |
| Ensemble Gene ID | ENSG00000099985 |
| RefSeq Protein Accession(s) | NP_001306037.1 |
| RefSeq mRNA Accession(s) | NM_001319108.1, NM_020530.5 |
| UniProt ID(s) | P13725 |
| UniGene ID(s) | Hs.248156 |
| HGNC ID(s) | HGNC:8506 |
| COSMIC ID Link(s) | OSM |
| KEGG Gene ID(s) | hsa:5008 |
| PharmGKB ID(s) | PA32836 |
| General Description of Recombinant Human Oncostatin M / OSM Protein. | |
| Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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