PDF DatasheetHuman AIMP1 / EMAP2 / SCYE1 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant AIMP1 / EMAP2 / SCYE1 based upon sequence from: Human
Host: QP10366 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human AIMP1 / EMAP2 / SCYE1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10366.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by the apoptotic effect using serum free human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of > 2.5 × 104 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SKPIDVSRLD LRIGCIITAR KHPDADSLYV EEVDVGEIAP RTVVSGLVNH VPLEQMQNRM VILLCNLKPA KMRGVLSQAM VMCASSPEKI EILAPPNGSV PGDRITFDAF PGEPDKELNP KKKIWEQIQP DLHTNDECVA TYKGVPFEVK GKGVCRAQTM SNSGIK
Purity: Greater than 98% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human AIMP1 / EMAP2 / SCYE1 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human AIMP1 / EMAP2 / SCYE1 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AIMP1 |
| Entrez Gene ID | 9255 |
| Ensemble Gene ID | ENSG00000164022 |
| RefSeq Protein Accession(s) | NP_001135887.1 |
| RefSeq mRNA Accession(s) | NM_001142415.1, NM_001142416.1, NM_004757.3, XM_017008835.1, XM_017008836.1 |
| UniProt ID(s) | Q12904 |
| HGNC ID(s) | HGNC:10648 |
| COSMIC ID Link(s) | AIMP1 |
| KEGG Gene ID(s) | hsa:9255 |
| PharmGKB ID(s) | PA35578 |
| General Description of Recombinant Human AIMP1 / EMAP2 / SCYE1 Protein. | |
| Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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