PDF DatasheetHuman TNFR1 / CD120a / TNFRSF1A Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant TNFR1 / CD120a / TNFRSF1A based upon sequence from: Human
Host: QP10374 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TNFR1 / CD120a / TNFRSF1A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10374.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.05 ug/ml, corresponding to a specific activity of > 2 × 104 IU/mg in the presence of 0.25 ng/mL of rHuTNF-alpha.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: IYPSGVIGLV PHLGDREKRD SVCPQGKYIH PQNNSICCTK CHKGTYLYND CPGPGQDTDC RECESGSFTA SENHLRHCLS CSKCRKEMGQ VEISSCTVDR DTVCGCRKNQ YRHYWSENLF QCFNCSLCLN GTVHLSCQEK QNTVCTCHAG FFLRENECVS CSNCKKSLEC TKLCLPQIEN VKGTEDSGTT
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TNFR1 / CD120a / TNFRSF1A Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TNFR1 / CD120a / TNFRSF1A Protein General Information | |
|---|---|
| Alternate Names | |
| TNFR1; CD120a; TNFRSF1A; TNF-R55; TNF-alphaR1; Tnfr1; p55-R; FPF; TNFRp55; TNF-R; TNF-R-I; TNF-R1; TNFAR; TNFR60; TNFalpha-R1; Tnfr-2; p55; CD120a; TNFRI | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF1A |
| Entrez Gene ID | 7132 |
| Ensemble Gene ID | ENSG00000067182 |
| RefSeq Protein Accession(s) | NP_001056.1 |
| RefSeq mRNA Accession(s) | NM_001065.3, NM_001346091.1, NM_001346092.1 |
| UniProt ID(s) | P19438 |
| UniGene ID(s) | Hs.279594 |
| HGNC ID(s) | HGNC:11916 |
| COSMIC ID Link(s) | TNFRSF1A |
| KEGG Gene ID(s) | hsa:7132 |
| PharmGKB ID(s) | PA36609 |
| General Description of Recombinant Human TNFR1 / CD120a / TNFRSF1A Protein. | |
| Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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