PDF DatasheetHuman TNFR2 / CD120b / TNFRSF1B Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant TNFR2 / CD120b / TNFRSF1B based upon sequence from: Human
Host: QP10375 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TNFR2 / CD120b / TNFRSF1B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10375.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.2 ug/ml, corresponding to a specific activity of > 5000 IU/mg in the presence of 0.25 ng/mL of rHuTNF-alpha.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MPAQVAFTPY APEPGSTCRL REYYDQTAQM CCSKCSPGQH AKVFCTKTSD TVCDSCEDST YTQLWNWVPE CLSCGSRCSS DQVETQACTR EQNRICTCRP GWYCALSKQE GCRLCAPLRK CRPGFGVARP GTETSDVVCK PCAPGTFSNT TSSTDICRPH QICNVVAIPG NASMDAVCTS TSPT
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TNFR2 / CD120b / TNFRSF1B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TNFR2 / CD120b / TNFRSF1B Protein General Information | |
|---|---|
| Alternate Names | |
| TNFR2; CD120b; TNFRSF1B; p75; TNF-alphaR2; Tnfr2; TNF-R75; CD120b; TNFalpha-R2; TNF-R2; TNF-R-II; TNFRII; TNFBR; TNFR80; Tnfr-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF1B |
| Entrez Gene ID | 7133 |
| Ensemble Gene ID | ENSG00000028137 |
| RefSeq Protein Accession(s) | NP_001057.1 |
| RefSeq mRNA Accession(s) | NM_001066.2 |
| UniProt ID(s) | P20333 |
| UniGene ID(s) | Hs.256278 |
| HGNC ID(s) | HGNC:11917 |
| COSMIC ID Link(s) | TNFRSF1B |
| KEGG Gene ID(s) | hsa:7133 |
| PharmGKB ID(s) | PA36610 |
| General Description of Recombinant Human TNFR2 / CD120b / TNFRSF1B Protein. | |
| Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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