PDF DatasheetHuman TNFR2 / CD120b / TNFRSF1B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TNFR2 / CD120b / TNFRSF1B based upon sequence from Human
Host: QP6814 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TNFR2 / CD120b / TNFRSF1B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6814.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val27 – Thr203
Amino Acid Sequence: VAFTPYAPEP GSTCRLREYY DQTAQMCCSK CSPGQHAKVF CTKTSDTVCD SCEDSTYTQL WNWVPECLSC GSRCSSDQVE TQACTREQNR ICTCRPGWYC ALSKQEGCRL CAPLRKCRPG FGVARPGTET SDVVCKPCAP GTFSNTTSST DICRPHQICN VVAIPGNASM DAVCTST
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human TNFR2 / CD120b / TNFRSF1B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TNFR2 / CD120b / TNFRSF1B Protein General Information | |
|---|---|
| Alternate Names | |
| TNFR2, CD120b, TNFRSF1B, p75, TNF-alphaR2, Tnfr2, TNF-R75, CD120b, TNFalpha-R2, TNF-R2, TNF-R-II, TNFRII, TNFBR, TNFR80, Tnfr-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF1B |
| Entrez Gene ID | 7133 |
| Ensemble Gene ID | ENSG00000028137 |
| RefSeq Protein Accession(s) | NP_001057.1 |
| RefSeq mRNA Accession(s) | NM_001066.2 |
| UniProt ID(s) | P20333 |
| UniGene ID(s) | Hs.256278 |
| HGNC ID(s) | HGNC:11917 |
| COSMIC ID Link(s) | TNFRSF1B |
| KEGG Gene ID(s) | hsa:7133 |
| PharmGKB ID(s) | PA36610 |
| General Description of Recombinant Human TNFR2 / CD120b / TNFRSF1B Protein. | |
| Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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