PDF DatasheetHuman Fibroblast growth factor 19 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Fibroblast growth factor 19 based upon sequence from: Human
Host: QP10383 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Fibroblast growth factor 19, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10383.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150 ng/ml, corresponding to a specific activity of > 6.7 × 103 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Fibroblast growth factor 19 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Fibroblast growth factor 19 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FGF19 |
| Entrez Gene ID | 9965 |
| Ensemble Gene ID | ENSG00000162344 |
| RefSeq Protein Accession(s) | NP_005108.1 |
| RefSeq mRNA Accession(s) | NM_005117.2 |
| UniProt ID(s) | O95750 |
| UniGene ID(s) | Hs.249200 |
| HGNC ID(s) | HGNC:3675 |
| COSMIC ID Link(s) | FGF19 |
| KEGG Gene ID(s) | hsa:9965 |
| PharmGKB ID(s) | PA28114 |
| General Description of Recombinant Human Fibroblast growth factor 19 Protein. | |
| Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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