PDF DatasheetHuman FGF21 / Fibroblast Growth Factor 21 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant FGF21 / Fibroblast Growth Factor 21 based upon sequence from: Human
Host: QP10384 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human FGF21 / Fibroblast Growth Factor 21, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10384.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 ug/ml, corresponding to a specific activity of > 2.0 × 103 IU/mg in the presence of 5 ug/ml of rMuKlotho-beta and 10 ug/ml of heparin.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA S
Purity: Greater than 96% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human FGF21 / Fibroblast Growth Factor 21 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human FGF21 / Fibroblast Growth Factor 21 Protein General Information | |
|---|---|
| Alternate Names | |
| FGF21; Fibroblast Growth Factor 21 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FGF21 |
| Entrez Gene ID | 26291 |
| Ensemble Gene ID | ENSG00000105550 |
| RefSeq Protein Accession(s) | NP_061986.1 |
| RefSeq mRNA Accession(s) | NM_019113.3 |
| UniProt ID(s) | Q9NSA1 |
| UniGene ID(s) | Hs.283015 |
| HGNC ID(s) | HGNC:3678 |
| COSMIC ID Link(s) | FGF21 |
| KEGG Gene ID(s) | hsa:26291 |
| PharmGKB ID(s) | PA28117 |
| General Description of Recombinant Human FGF21 / Fibroblast Growth Factor 21 Protein. | |
| Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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