PDF DatasheetHuman Protein CYR61 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Protein CYR61 based upon sequence from: Human
Host: QP10401 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Protein CYR61, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10401.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine Balb/3T3 cells is less than 3.0 ug/ml, corresponding to a specific activity of > 330 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Protein CYR61 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered citrate buffer solution, 300 mM NaCl, pH 3.0, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein CYR61 Protein General Information | |
|---|---|
| Alternate Names | |
| CCN1; IGFBP10; GIG1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CYR61 |
| Entrez Gene ID | 3491 |
| Ensemble Gene ID | ENSG00000142871 |
| RefSeq Protein Accession(s) | NP_001545.2 |
| RefSeq mRNA Accession(s) | NM_001554.4 |
| UniProt ID(s) | O00622 |
| UniGene ID(s) | Hs.8867 |
| HGNC ID(s) | HGNC:2654 |
| COSMIC ID Link(s) | CYR61 |
| KEGG Gene ID(s) | hsa:3491 |
| PharmGKB ID(s) | PA27126 |
| General Description of Recombinant Human Protein CYR61 Protein. | |
| Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.