PDF DatasheetHuman Protein CYR61 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein CYR61 based upon sequence from Human
Host: QP5909 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein CYR61, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5909.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Thr25 – Asp381
Amino Acid Sequence: TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Protein CYR61 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein CYR61 Protein General Information | |
|---|---|
| Alternate Names | |
| CCN1, IGFBP10, GIG1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CYR61 |
| Entrez Gene ID | 3491 |
| Ensemble Gene ID | ENSG00000142871 |
| RefSeq Protein Accession(s) | NP_001545.2 |
| RefSeq mRNA Accession(s) | NM_001554.4 |
| UniProt ID(s) | O00622 |
| UniGene ID(s) | Hs.8867 |
| HGNC ID(s) | HGNC:2654 |
| COSMIC ID Link(s) | CYR61 |
| KEGG Gene ID(s) | hsa:3491 |
| PharmGKB ID(s) | PA27126 |
| General Description of Recombinant Human Protein CYR61 Protein. | |
| Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.