PDF DatasheetMouse Bcl-2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Bcl-2 based upon sequence from Mouse
Host: QP5710 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Bcl-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5710.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly5 – Pro205
Amino Acid Sequence: GRTGYDNREI VMKYIHYKLS QRGYEWDAGD ADAAPLGAAP TPGIFSFQPE SNPMPAVHRD MAARTSPLRP LVATAGPALS PVPPVVHLTL RRAGDDFSRR YRRDFAEMSS QLHLTPFTAR GRFATVVEEL FRDGVNWGRI VAFFEFGGVM CVESVNREMS PLVDNIALWM TEYLNRHLHT WIQDNGGWDA FVELYGPSMR P
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Bcl-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Bcl-2 Protein General Information | |
|---|---|
| Alternate Names | |
| Bcl-2, Bcl-2, PPP1R50 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Bcl2 |
| Entrez Gene ID | 12043 |
| Ensemble Gene ID | ENSMUSG00000057329 |
| RefSeq Protein Accession(s) | NP_033871.2 |
| RefSeq mRNA Accession(s) | NM_009741.5 |
| UniProt ID(s) | P10417 |
| UniGene ID(s) | Mm.257460 |
| COSMIC ID Link(s) | Bcl2 |
| KEGG Gene ID(s) | mmu:12043 |
| General Description of Recombinant Mouse Bcl-2 Protein. | |
| Suppresses apoptosis in a variety of cell systs including factor-dependent lymphohatopoietic and neural cells. Regulates cell death by controlling the mitochondrial mbrane permeability. Appears to function in a feedback loop syst with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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![Staining with mouse monoclonal Bcl-2 [Clone 100/D5] antibody in formalin-fixed paraffin-embedded Jurkat cells. Staining is intercellular (red) with isotype control (green).](https://enquirebio.com/wp-content/uploads/2019/01/Bcl-2 Flow Cytometry Jurkat Cells (100 D5)-150x150.jpg)
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![Staining with Mouse Monoclonal BCL-2 [Clone 124] Antibody in formalin-fixed paraffin-embedded human non-Hodgkins Lymphoma. Note cytoplasmic and nuclear membrane staining.](https://cdn-enquirebio.pressidium.com/wp-content/uploads/2017/04/BCL-2-IHC-Antibody-Clone-124-150x150.jpeg)
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![Staining with Mouse Monoclonal BCL-2 [100 D5 + 124] Antibody in formalin-fixed paraffin-embedded human non-Hodgkins Lymphoma. Note cytoplasmic and nuclear membrane staining.](https://enquirebio.com/wp-content/uploads/2019/01/Bcl-2 IHC human non-Hodgkins Lymphoma (100 D5 + 124)-150x150.jpg)
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