PDF DatasheetHuman C5a / Complement 5a Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant C5a / Complement 5a based upon sequence from Human
Host: QP5737 protein expressed in E.coli, Mammal..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) C5a / Complement 5a, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5737.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Thr678 – Arg751
Amino Acid Sequence: TLQKKIEEIA AKYKHSVVKK CCYDGACVNN DETCEQRAAR ISLGPRCIKA FTECCVVASQ LRANISHKDM QLGR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human C5a / Complement 5a Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human C5a / Complement 5a Protein General Information | |
|---|---|
| Alternate Names | |
| C5a, Complement 5a, C5a, ECLZB, C5D, CPAMD4, C5b | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | C5 |
| Entrez Gene ID | 727 |
| Ensemble Gene ID | ENSG00000106804 |
| RefSeq Protein Accession(s) | NP_001304092.1 |
| RefSeq mRNA Accession(s) | NM_001317163.1, NM_001735.2 |
| UniProt ID(s) | P01031 |
| UniGene ID(s) | Hs.494997 |
| HGNC ID(s) | HGNC:1331 |
| COSMIC ID Link(s) | C5 |
| KEGG Gene ID(s) | hsa:727 |
| PharmGKB ID(s) | PA25911 |
| General Description of Recombinant Human C5a / Complement 5a Protein. | |
| Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
|
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.