PDF DatasheetHuman CD44 / HCAM Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CD44 / HCAM based upon sequence from Human
Isoform: Isoform 4
Host: QP5788 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD44 / HCAM, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5788.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details). of Isoform 4
Expression Region: Gln21 – Glu606
Amino Acid Sequence: QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATSTSSNTIS AGWEPNEENE DERDRHLSFS GSGIDDDEDF ISSTISTTPR AFDHTKQNQD WTQWNPSHSN PEVLLQTTTR MTDVDRNGTT AYEGNWNPEA HPPLIHHEHH EEEETPHSTS TIQATPSSTT EETATQKEQW FGNRWHEGYR QTPKEDSHST TGTAAASAHT SHPMQGRTTP SPEDSSWTDF FNPISHPMGR GHQAGRRMDM DSSHSITLQP TANPNTGLVE DLDRTGPLSM TTQQSNSQSF STSHEGLEED KDHPTTSTLT SSNRNDVTGG RRDPNHSEGS TTLLEGYTSH YPHTKESRTF IPVTSAKTGS FGVTAVTVGD SNSNVNRSLS GDQDTFHPSG GSHTTHGSES DGHSHGSQEG GANTTSGPIR TPQIPE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human CD44 / HCAM Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD44 / HCAM Protein General Information | |
|---|---|
| Alternate Names | |
| CD44, HCAM, CDW44, HUTCH-I, IN, LHR, CSPG8, MC56, MDU2, MDU3, ECMR-III, MIC4, Pgp1, HCELL | |
| Molecular Weight | |
| Isoform 4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD44 |
| Entrez Gene ID | 960 |
| Ensemble Gene ID | ENSG00000026508 |
| RefSeq Protein Accession(s) | NP_000601.3 |
| RefSeq mRNA Accession(s) | NM_000610.3, NM_001001389.1, NM_001001390.1, NM_001001391.1, NM_001001392.1, NM_001202555.1, NM_001202556.1, NM_001202557.1, XM_011520488.1 |
| UniProt ID(s) | P16070 |
| UniGene ID(s) | Hs.502328 |
| HGNC ID(s) | HGNC:1681 |
| COSMIC ID Link(s) | CD44 |
| KEGG Gene ID(s) | hsa:960 |
| PharmGKB ID(s) | PA26221 |
| General Description of Recombinant Human CD44 / HCAM Protein. | |
| Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hatopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
![Analysis of Mass Spec data (dashed-line) of fractions stained with CD44 / HCAM MS-QAVA™ monoclonal antibody [Clone: HCAM/918] (solid-line), reveals that less than 12.6% of signal is attributable to non-specific binding of anti-CD44 / HCAM Std. Anti-Human, Primate [Clone HCAM/918] to targets other than CD44 protein. Even frequently cited antibodies have much greater non-specific interactions, averaging over 30%. Data in image is from analysis in Jurkat, U202 and HeLa cells.](https://cdn-enquirebio.pressidium.com/wp-content/uploads/2017/10/enQuire-Bio-960-MSM2-P1-anti-CD44-HCAM-antibody-150x150.png)
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