PDF DatasheetHuman Steroid 17-alpha-hydroxylase / 17,20 lyase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Steroid 17-alpha-hydroxylase / 17,20 lyase based upon sequence from Human
Host: QP5905 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Steroid 17-alpha-hydroxylase/17,20 lyase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5905.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly24 – Thr508
Amino Acid Sequence: GAKYPKSLLS LPLVGSLPFL PRHGHMHNNF FKLQKKYGPI YSVRMGTKTT VIVGHHQLAK EVLIKKGKDF SGRPQMATLD IASNNRKGIA FADSGAHWQL HRRLAMATFA LFKDGDQKLE KIICQEISTL CDMLATHNGQ SIDISFPVFV AVTNVISLIC FNTSYKNGDP ELNVIQNYNE GIIDNLSKDS LVDLVPWLKI FPNKTLEKLK SHVKIRNDLL NKILENYKEK FRSDSITNML DTLMQAKMNS DNGNAGPDQD SELLSDNHIL TTIGDIFGAG VETTTSVVKW TLAFLLHNPQ VKKKLYEEID QNVGFSRTPT ISDRNRLLLL EATIREVLRL RPVAPMLIPH KANVDSSIGE FAVDKGTEVI INLWALHHNE KEWHQPDQFM PERFLNPAGT QLISPSVSYL PFGAGPRSCI GEILARQELF LIMAWLLQRF DLEVPDDGQL PSLEGIPKVV FLIDSFKVKI KVRQAWREAQ AEGST
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Steroid 17-alpha-hydroxylase / 17,20 lyase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Steroid 17-alpha-hydroxylase / 17,20 lyase Protein (24-508aa) General Information | |
|---|---|
| Alternate Names | |
| CPT7, P450C17, S17AH, CYP17 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CYP17A1 |
| Entrez Gene ID | 1586 |
| Ensemble Gene ID | ENSG00000148795 |
| RefSeq Protein Accession(s) | NP_000093.1 |
| RefSeq mRNA Accession(s) | NM_000102.3 |
| UniProt ID(s) | P05093 |
| UniGene ID(s) | Hs.438016 |
| HGNC ID(s) | HGNC:2593 |
| COSMIC ID Link(s) | CYP17A1 |
| KEGG Gene ID(s) | hsa:1586 |
| PharmGKB ID(s) | PA27090 |
| General Description of Recombinant Human Steroid 17-alpha-hydroxylase / 17,20 lyase Protein (24-508aa). | |
| Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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