PDF DatasheetHuman Kynurenine 3-monooxygenase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Kynurenine 3-monooxygenase based upon sequence from Human
Host: QP6271 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Kynurenine 3-monooxygenase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6271.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Arg486
Amino Acid Sequence: MDSSVIQRKK VAVIGGGLVG SLQACFLAKR NFQIDVYEAR EDTRVATFTR GRSINLALSH RGRQALKAVG LEDQIVSQGI PMRARMIHSL SGKKSAIPYG TKSQYILSVS RENLNKDLLT AAEKYPNVKM HFNHRLLKCN PEEGMITVLG SDKVPKDVTC DLIVGCDGAY STVRSHLMKK PRFDYSQQYI PHGYMELTIP PKNGDYAMEP NYLHIWPRNT FMMIALPNMN KSFTCTLFMP FEEFEKLLTS NDVVDFFQKY FPDAIPLIGE KLLVQDFFLL PAQPMISVKC SSFHFKSHCV LLGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFSNDLSL CLPVFSRLRI PDDHAISDLS MYNYIEMRAH VNSSWFIFQK NMERFLHAIM PSTFIPLYTM VTFSRIRYHE AVQRWHWQKK VINKGLFFLG SLIAISSTYL LIHYMSPRSF LRLRRPWNWI AHFRNTTCFP AKAVDSLEQI SNLISR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Kynurenine 3-monooxygenase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Kynurenine 3-monooxygenase Protein General Information | |
|---|---|
| Alternate Names | |
| dJ317G22.1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KMO |
| Entrez Gene ID | 8564 |
| Ensemble Gene ID | ENSG00000117009 |
| RefSeq Protein Accession(s) | NP_003670.2 |
| RefSeq mRNA Accession(s) | NM_003679.4 |
| UniProt ID(s) | O15229 |
| UniGene ID(s) | Hs.731056 |
| HGNC ID(s) | HGNC:6381 |
| COSMIC ID Link(s) | KMO |
| KEGG Gene ID(s) | hsa:8564 |
| PharmGKB ID(s) | PA30172 |
| General Description of Recombinant Human Kynurenine 3-monooxygenase Protein. | |
| Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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