PDF DatasheetRat Kynurenine 3-monooxygenase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Kynurenine 3-monooxygenase based upon sequence from Rat
Host: QP6272 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Kynurenine 3-monooxygenase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6272.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Lys384
Amino Acid Sequence: MASSDTEGKR VVVIGGGLVG ALNACFLAKR NFQVDVYEAR EDIRVANFMR GRSINLALSY RGRQALKAVG LEDQIVSKGV PMKARMIHSL SGKKSAIPYG NKSQYILSIS REKLNKDLLT AVESYPNAKV HFGHKLSKCC PEEGILTMLG PNKVPRDITC DLIVGCDGAY STVRAHLMKK PRFDYSQQYI PHGYMELTIP PKNGEYAMEP NCLHIWPRNA FMMIALPNMD KSFTCTLFMS FEEFEKLPTH SDVLDFFQKN FPDAIPLMGE QALMRDFFLL PAQPMISVKC SPFHLKSRCV LMGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFNNDLSV CLPEFSRFRI PDDHAISDLS MYNYIEMRAH VNSRWFLFQR LLDK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat Kynurenine 3-monooxygenase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Kynurenine 3-monooxygenase Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KMO |
| Entrez Gene ID | 59113 |
| Ensemble Gene ID | ENSRNOG00000003709 |
| RefSeq Protein Accession(s) | NP_067604.1 |
| RefSeq mRNA Accession(s) | NM_021593.1 |
| UniProt ID(s) | O88867 |
| UniGene ID(s) | Rn.35029 |
| COSMIC ID Link(s) | KMO |
| KEGG Gene ID(s) | rno:59113 |
| General Description of Recombinant Rat Kynurenine 3-monooxygenase Protein. | |
| Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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