PDF DatasheetBovine Cytokeratin 17 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cytokeratin 17 based upon sequence from Bovine
Host: QP6277 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Bos taurus (Bovine) Cytokeratin 17, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6277.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – His441
Amino Acid Sequence: MTTTIRHFSS GSIKGSSGLA GGSSRSCRVS GSLGGGSCRL GSAGGLGSGL GGSSYSSCYS FGSGGGYGSG GYVSGGYGGG FGGVDGLLVG GEKATMQNLN DRLASYLDKV RALEEANTEL ELKIRDWYQK QAPGPAPDYS SYFKTIEDLR NKIHTATVDN ANLLLQIDNA RLAADDFRTK FETEQALRVS VEADINGLRR VLDELTLARA DLEMQIENLK EELAYLRKNH EEEMKALRGQ VGGEINVEMD AAPGVDLSRI LNEMRDQYEK MAEKNRKDAE DWFFSKTEEL NREVATNSEL VQSGKSEISE LRRTLQALEI ELQSQLSMKA SLEGSLAETE NRYCMQLSQI QGLIGSVEEQ LAQLRCEMEQ QNQEYKILLD VKTRLEQEIA TYRRLLEGED AHLTQYKTKE PVTTRQVRTI VEEVQDGRVI SSREQVHQTS H
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Bovine Cytokeratin 17 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Bovine Cytokeratin 17 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KRT17 |
| Entrez Gene ID | 281889 |
| RefSeq Protein Accession(s) | NP_001098792.1 |
| RefSeq mRNA Accession(s) | NM_001105322.1, XM_005220671.2 |
| UniProt ID(s) | A1L595 |
| UniGene ID(s) | Bt.91540 |
| COSMIC ID Link(s) | KRT17 |
| KEGG Gene ID(s) | bta:281889 |
| General Description of Recombinant Bovine Cytokeratin 17 Protein. | |
| Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial “st cells”. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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