PDF DatasheetHuman Cytokeratin 18 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cytokeratin 18 based upon sequence from Human
Host: QP6278 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Cytokeratin 18, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6278.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Thr11 – His430
Amino Acid Sequence: TNYRSLGSVQ APSYGARPVS SAASVYAGAG GSGSRISVSR STSFRGGMGS GGLATGIAGG LAGMGGIQNE KETMQSLNDR LASYLDRVRS LETENRRLES KIREHLEKKG PQVRDWSHYF KIIEDLRAQI FANTVDNARI VLQIDNARLA ADDFRVKYET ELAMRQSVEN DIHGLRKVID DTNITRLQLE TEIEALKEEL LFMKKNHEEE VKGLQAQIAS SGLTVEVDAP KSQDLAKIMA DIRAQYDELA RKNREELDKY WSQQIEESTT VVTTQSAEVG AAETTLTELR RTVQSLEIDL DSMRNLKASL ENSLREVEAR YALQMEQLNG ILLHLESELA QTRAEGQRQA QEYEALLNIK VKLEAEIATY RRLLEDGEDF NLGDALDSSN SMQTIQKTTT RRIVDGKVVS ETNDTKVLRH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Cytokeratin 18 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Cytokeratin 18 Protein (11-430aa) General Information | |
|---|---|
| Alternate Names | |
| Cytokeratin 18, CYK18, K18, CK-18 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KRT18 |
| Entrez Gene ID | 3875 |
| Ensemble Gene ID | ENSG00000111057 |
| RefSeq Protein Accession(s) | NP_000215.1 |
| RefSeq mRNA Accession(s) | NM_000224.2, NM_199187.1 |
| UniProt ID(s) | P05783 |
| UniGene ID(s) | Hs.406013 |
| HGNC ID(s) | HGNC:6430 |
| COSMIC ID Link(s) | KRT18 |
| KEGG Gene ID(s) | hsa:3875 |
| PharmGKB ID(s) | PA30217 |
| General Description of Recombinant Human Cytokeratin 18 Protein (11-430aa). | |
| Involved in the uptake of thrombin-antithrombin complexes by hepatic cells . When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma mbrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
![Analysis of Mass Spec data (dashed-line) of fractions stained with Cytokeratin 18 MS-QAVA™ monoclonal antibody [Clone: B23.1] (solid-line), reveals that less than 13.5% of signal is attributable to non-specific binding of anti-Cytokeratin 18 [Clone B23.1] to targets other than KRT18 protein. Even frequently cited antibodies have much greater non-specific interactions, averaging over 30%. Data in image is from analysis in A431, RT4 and MCF7 cells.](https://cdn-enquirebio.pressidium.com/wp-content/uploads/2017/10/enQuire-Bio-3875-MSM9-P1-anti-Cytokeratin-18-antibody-150x150.png)
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