PDF DatasheetHuman Perforin-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Perforin-1 based upon sequence from Human
Host: QP6525 protein expressed in E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Perforin-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6525.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Pro22 – Trp555
Amino Acid Sequence: PCHTAARSEC KRSHKFVPGA WLAGEGVDVT SLRRSGSFPV DTQRFLRPDG TCTLCENALQ EGTLQRLPLA LTNWRAQGSG CQRHVTRAKV SSTEAVARDA ARSIRNDWKV GLDVTPKPTS NVHVSVAGSH SQAANFAAQK THQDQYSFST DTVECRFYSF HVVHTPPLHP DFKRALGDLP HHFNASTQPA YLRLISNYGT HFIRAVELGG RISALTALRT CELALEGLTD NEVEDCLTVE AQVNIGIHGS ISAEAKACEE KKKKHKMTAS FHQTYRERHS EVVGGHHTSI NDLLFGIQAG PEQYSAWVNS LPGSPGLVDY TLEPLHVLLD SQDPRREALR RALSQYLTDR ARWRDCSRPC PPGRQKSPRD PCQCVCHGSA VTTQDCCPRQ RGLAQLEVTF IQAWGLWGDW FTATDAYVKL FFGGQELRTS TVWDNNNPIW SVRLDFGDVL LATGGPLRLQ VWDQDSGRDD DLLGTCDQAP KSGSHEVRCN LNHGHLKFRY HARCLPHLGG GTCLDYVPQM LLGEPPGNRS GAVW
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Perforin-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol OR, if lyophilized, Tris-based buffer, 6% Trehalose
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Perforin-1 Protein General Information | |
|---|---|
| Alternate Names | |
| HPLH2, PFN1, PFP, P1, FLH2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Prf1 |
| Entrez Gene ID | 5551 |
| Ensemble Gene ID | ENSG00000180644 |
| RefSeq Protein Accession(s) | NP_001076585.1 |
| RefSeq mRNA Accession(s) | NM_001083116.1, NM_005041.4 |
| UniProt ID(s) | P14222 |
| UniGene ID(s) | Hs.2200 |
| HGNC ID(s) | HGNC:9360 |
| COSMIC ID Link(s) | Prf1 |
| KEGG Gene ID(s) | hsa:5551 |
| PharmGKB ID(s) | PA33732 |
| General Description of Recombinant Human Perforin-1 Protein. | |
| Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune syst, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the mbrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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