PDF DatasheetHuman STAT3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant STAT3 based upon sequence from Human
Host: QP6735 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) STAT3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6735.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu50 – Leu240
Amino Acid Sequence: ESHATLVFHN LLGEIDQQYS RFLQESNVLY QHNLRRIKQF LQSRYLEKPM EIARIVARCL WEESRLLQTA ATAAQQGGQA NHPTAAVVTE KQQMLEQHLQ DVRKRVQDLE QKMKVVENLQ DDFDFNYKTL KSQGDMQDLN GNNQSVTRQK MQQLEQMLTA LDQMRRSIVS ELAGLLSAME YVQKTLTDEE L
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human STAT3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human STAT3 Protein General Information | |
|---|---|
| Alternate Names | |
| APRF, HIES, ADMIO, ADMIO1, Signal transducer and activator of transcription | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | STAT3 |
| Entrez Gene ID | 6774 |
| Ensemble Gene ID | ENSG00000168610 |
| RefSeq Protein Accession(s) | NP_003141.2 |
| RefSeq mRNA Accession(s) | NM_003150.3, NM_139276.2, NM_213662.1, XM_005257616.3, XM_005257617.3, XM_011525145.2, XM_011525146.2, XM_017024972.1, XM_017024975.1 |
| UniProt ID(s) | P40763 |
| UniGene ID(s) | Hs.463059 |
| HGNC ID(s) | HGNC:11364 |
| COSMIC ID Link(s) | STAT3 |
| KEGG Gene ID(s) | hsa:6774 |
| PharmGKB ID(s) | PA337 |
| General Description of Recombinant Human STAT3 Protein. | |
| Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elents identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic domain STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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