PDF DatasheetHuman STAT3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant STAT3 based upon sequence from: Human
Host: QP9416 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) STAT3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9416.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Met770
Amino Acid Sequence: MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDME LTSECATSPM
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human STAT3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human STAT3 Protein General Information | |
|---|---|
| Alternate Names | |
| APRF; HIES; ADMIO; ADMIO1; Signal transducer and activator of transcription | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | STAT3 |
| Entrez Gene ID | 6774 |
| Ensemble Gene ID | ENSG00000168610 |
| RefSeq Protein Accession(s) | NP_003141.2 |
| RefSeq mRNA Accession(s) | NM_003150.3, NM_139276.2, NM_213662.1, XM_005257616.3, XM_005257617.3, XM_011525145.2, XM_011525146.2, XM_017024972.1, XM_017024975.1 |
| UniProt ID(s) | P40763 |
| UniGene ID(s) | Hs.463059 |
| HGNC ID(s) | HGNC:11364 |
| COSMIC ID Link(s) | STAT3 |
| KEGG Gene ID(s) | hsa:6774 |
| PharmGKB ID(s) | PA337 |
| General Description of Recombinant Human STAT3 Protein. | |
| Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elents identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic domain STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.