PDF DatasheetHuman Regulatory protein E2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Regulatory protein E2 based upon sequence from: Human
Host: QP7408 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Regulatory protein E2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7408.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ile365
Amino Acid Sequence: METLCQRLNV CQDKILTHYE NDSTDLRDHI DYWKHMRLEC AIYYKAREMG FKHINHQVVP TLAVSKNKAL QAIELQLTLE TIYNSQYSNE KWTLQDVSLE VYLTAPTGCI KKHGYTVEVQ FDGDICNTMH YTNWTHIYIC EEASVTVVEG QVDYYGLYYV HEGIRTYFVQ FKDDAEKYSK NKVWEVHAGG QVILCPTSVF SSNEVSSPEI IRQHLANHPA ATHTKAVALG TEETQTTIQR PRSEPDTGNP CHTTKLLHRD SVDSAPILTA FNSSHKGRIN CNSNTTPIVH LKGDANTLKC LRYRFKKHCT LYTAVSSTWH WTGHNVKHKS AIVTLTYDSE WQRDQFLSQV KIPKTITVST GFMSI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Regulatory protein E2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Regulatory protein E2 Protein General Information | |
|---|---|
| Alternate Names | |
| HpV16gp4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | E2 |
| Entrez Gene ID | 1489080 |
| RefSeq Protein Accession(s) | NP_041328.1 |
| RefSeq mRNA Accession(s) | NC_001526.4 |
| UniProt ID(s) | P03120 |
| KEGG Gene ID(s) | vg:1489080 |
| General Description of Recombinant Human Regulatory protein E2 Protein. | |
| Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is roved from DNA. E2 also regulates viral transcription through binding to the E2RE response elent (5′-ACCNNNNNNGGT-3′) present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE’s position with regards to proximal promoter elents including the TATA-box. Repression occurs by sterically hindering the assbly of the transcription initiation complex. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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