PDF DatasheetHuman TIGIT / VSTM3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TIGIT / VSTM3 based upon sequence from: Human
Host: QP7657 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TIGIT / VSTM3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7657.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Met22 – Pro141
Amino Acid Sequence: MMTGTIETTG NISAEKGGSI ILQCHLSSTT AQVTQVNWEQ QDQLLAICNA DLGWHISPSF KDRVAPGPGL GLTLQSLTVN DTGEYFCIYH TYPDGTYTGR IFLEVLESSV AEHGARFQIP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TIGIT / VSTM3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TIGIT / VSTM3 Protein General Information | |
|---|---|
| Alternate Names | |
| TIGIT; VSTM3; Vstm3; ENSMUSG00000071552 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TIGIT |
| Entrez Gene ID | 201633 |
| Ensemble Gene ID | ENSG00000181847 |
| RefSeq Protein Accession(s) | NP_776160.2 |
| RefSeq mRNA Accession(s) | NM_173799.3 |
| UniProt ID(s) | Q495A1 |
| UniGene ID(s) | Hs.421750 |
| HGNC ID(s) | HGNC:26838 |
| COSMIC ID Link(s) | TIGIT |
| KEGG Gene ID(s) | hsa:201633 |
| PharmGKB ID(s) | PA164726482 |
| General Description of Recombinant Human TIGIT / VSTM3 Protein. | |
| Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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