PDF DatasheetHuman Mixed lineage kinase domain-like protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Mixed lineage kinase domain-like protein based upon sequence from: Human
Host: QP7971 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Mixed lineage kinase domain-like protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7971.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys471
Amino Acid Sequence: MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG ASWAQEDQQD ADEDRRAFQM LRRDNEKIEA SLRRLEINMK EIKETLRQYL PPKCMQEIPQ EQIKEIKKEQ LSGSPWILLR ENEVSTLYKG EYHRAPVAIK VFKKLQAGSI AIVRQTFNKE IKTMKKFESP NILRIFGICI DETVTPPQFS IVMEYCELGT LRELLDREKD LTLGKRMVLV LGAARGLYRL HHSEAPELHG KIRSSNFLVT QGYQVKLAGF ELRKTQTSMS LGTTREKTDR VKSTAYLSPQ ELEDVFYQYD VKSEIYSFGI VLWEIATGDI PFQGCNSEKI RKLVAVKRQQ EPLGEDCPSE LREIIDECRA HDPSVRPSVD EILKKLSTFS K
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Mixed lineage kinase domain-like protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Mixed lineage kinase domain-like protein Protein General Information | |
|---|---|
| Alternate Names | |
| hMLKL | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MLKL |
| Entrez Gene ID | 197259 |
| Ensemble Gene ID | ENSG00000168404 |
| RefSeq Protein Accession(s) | NP_001135969.1 |
| RefSeq mRNA Accession(s) | NM_001142497.2, NM_152649.3, XM_005255834.3 |
| UniProt ID(s) | Q8NB16 |
| UniGene ID(s) | Hs.119878 |
| HGNC ID(s) | HGNC:26617 |
| COSMIC ID Link(s) | MLKL |
| KEGG Gene ID(s) | hsa:197259 |
| PharmGKB ID(s) | PA142671349 |
| General Description of Recombinant Human Mixed lineage kinase domain-like protein Protein. | |
| Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma mbrane and execution of programmed necrosis characterized by calcium influx and plasma mbrane damage. Does not have protein kinase activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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