PDF DatasheetMouse Mixed lineage kinase domain-like protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Mixed lineage kinase domain-like protein based upon sequence from Mouse
Host: QP9886 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Mixed lineage kinase domain-like protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9886.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val472
Amino Acid Sequence: MDKLGQIIKL GQLIYEQCEK MKYCRKQCQR LGNRVHGLLQ PLQRLQAQGK KNLPDDITAA LGRFDEVLKE ANQQIEKFSK KSHIWKFVSV GNDKILFHEV NEKLRDVWEE LLLLLQVYHW NTVSDVSQPA SWQQEDRQDA EEDGNENMKV ILMQLQISVE EINKTLKQCS LKPTQEIPQD LQIKEIPKEH LGPPWTKLKT SKMSTIYRGE YHRSPVTIKV FNNPQAESVG IVRFTFNDEI KTMKKFDSPN ILRIFGICID QTVKPPEFSI VMEYCELGTL RELLDREKDL TMSVRSLLVL RAARGLYRLH HSETLHRNIS SSSFLVAGGY QVKLAGFELS KTQNSISRTA KSTKAERSSS TIYVSPERLK NPFCLYDIKA EIYSFGIVLW EIATGKIPFE GCDSKKIREL VAEDKKQEPV GQDCPELLRE IINECRAHEP SQRPSVDGRS LSGRERILER LSAVEESTDK KV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Mixed lineage kinase domain-like protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Mixed lineage kinase domain-like protein Protein General Information | |
|---|---|
| Alternate Names | |
| 9130019I15Rik | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MLKL |
| Entrez Gene ID | 74568 |
| Ensemble Gene ID | ENSMUSG00000012519 |
| RefSeq Protein Accession(s) | NP_001297542.1 |
| RefSeq mRNA Accession(s) | NM_001310613.1, NM_029005.3, XM_006531442.2 |
| UniProt ID(s) | Q9D2Y4 |
| UniGene ID(s) | Mm.207971 |
| COSMIC ID Link(s) | MLKL |
| KEGG Gene ID(s) | mmu:74568 |
| General Description of Recombinant Mouse Mixed lineage kinase domain-like protein Protein. | |
| Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma mbrane and execution of programmed necrosis characterized by calcium influx and plasma mbrane damage. Does not have protein kinase activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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