PDF DatasheetHuman GRK2 / ADRBK1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant GRK2 / ADRBK1 based upon sequence from: Human
Host: QP8340 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) GRK2 / ADRBK1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8340.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala2 – Cys221
Amino Acid Sequence: ADLEAVLADV SYLMAMEKSK ATPAARASKK ILLPEPSIRS VMQKYLEDRG EVTFEKIFSQ KLGYLLFRDF CLNHLEEARP LVEFYEEIKK YEKLETEEER VARSREIFDS YIMKELLACS HPFSKSATEH VQGHLGKKQV PPDLFQPYIE EICQNLRGDV FQKFIESDKF TRFCQWKNVE LNIHLTMNDF SVHRIIGRGG FGEVYGCRKA DTGKMYAMKC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GRK2 / ADRBK1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human GRK2 / ADRBK1 Protein General Information | |
|---|---|
| Alternate Names | |
| GRK2; ADRBK1; BETA-ARK1; ADRBK1; BARK1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ADRBK1 |
| Entrez Gene ID | 156 |
| Ensemble Gene ID | ENSG00000173020 |
| RefSeq Protein Accession(s) | NP_001610.2 |
| RefSeq mRNA Accession(s) | NM_001619.3 |
| UniProt ID(s) | P25098 |
| UniGene ID(s) | Hs.83636 |
| HGNC ID(s) | HGNC:289 |
| COSMIC ID Link(s) | ADRBK1 |
| KEGG Gene ID(s) | hsa:156 |
| PharmGKB ID(s) | PA40 |
| General Description of Recombinant Human GRK2 / ADRBK1 Protein. | |
| Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of th. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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