PDF DatasheetHuman HMGB1 / HMG1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HMGB1 / HMG1 based upon sequence from: Human
Host: QP8377 protein expressed in E. coli (GST-tag) or Hi5 cells (His-tag).
Tag: GST or His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) HMGB1 / HMG1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8377.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Lys8 – Glu179
Amino Acid Sequence: KPRGKMSSYA FFVQTCREEH KKKHPDASVN FSEFSKKCSE RWKTMSAKEK GKFEDMAKAD KARYEREMKT YIPPKGETKK KFKDPNAPKR PPSAFFLFCS EYRPKIKGEH PGLSIGDVAK KLGEMWNNTA ADDKQPYEKK AAKLKEKYEK DIAAYRAKGK PDAAKKGVVK AE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human HMGB1 / HMG1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HMGB1 / HMG1 Protein General Information | |
|---|---|
| Alternate Names | |
| HMGB1; HMG1; HMG3; SBP-1; HMG-1; HMG1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HMGB1 |
| Entrez Gene ID | 3146 |
| Ensemble Gene ID | ENSG00000189403 |
| RefSeq Protein Accession(s) | NP_001300821.1 |
| RefSeq mRNA Accession(s) | NM_001313892.1, NM_001313893.1, NM_002128.5 |
| UniProt ID(s) | P09429 |
| UniGene ID(s) | Hs.434102 |
| HGNC ID(s) | HGNC:4983 |
| COSMIC ID Link(s) | HMGB1 |
| KEGG Gene ID(s) | hsa:3146 |
| PharmGKB ID(s) | PA188 |
| General Description of Recombinant Human HMGB1 / HMG1 Protein. | |
| DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type Cytoplasmic domain processes in developing cells . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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