PDF DatasheetHuman Angiopoietin-2 / ANG2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Angiopoietin-2 / ANG2 based upon sequence from: Human
Host: QP8512 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Angiopoietin-2 / ANG2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8512.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Tyr19 – Lys485
Amino Acid Sequence: YNNFRKSMDS IGKKQYQVQH GSCSYTFLLP EMDNCRSSSS PYVSNAVQRD APLEYDDSVQ RLQVLENIME NNTQWLMKLE NYIQDNMKKE MVEIQQNAVQ NQTAVMIEIG TNLLNQTAEQ TRKLTDVEAQ VLNQTTRLEL QLLEHSLSTN KLEKQILDQT SEINKLQDKN SFLEKKVLAM EDKHIIQLQS IKEEKDQLQV LVSKQNSIIE ELEKKIVTAT VNNSVLQKQQ HDLMETVNNL LTMMSTSNSA KDPTVAKEEQ ISFRDCAEVF KSGHTTNGIY TLTFPNSTEE IKAYCDMEAG GGGWTIIQRR EDGSVDFQRT WKEYKVGFGN PSGEYWLGNE FVSQLTNQQR YVLKIHLKDW EGNEAYSLYE HFYLSSEELN YRIHLKGLTG TAGKISSISQ PGNDFSTKDG DNDKCICKCS QMLTGGWWFD ACGPSNLNGM YYPQRQNTNK FNGIKWYYWK GSGYSLK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Angiopoietin-2 / ANG2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Angiopoietin-2 / ANG2 Protein General Information | |
|---|---|
| Alternate Names | |
| Angiopoietin-2; ANG2; Agpt2; Ang2; Ang-2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ANGPT2 |
| Entrez Gene ID | 285 |
| Ensemble Gene ID | ENSG00000091879 |
| RefSeq Protein Accession(s) | NP_001112359.1 |
| RefSeq mRNA Accession(s) | NM_001118887.1, NM_001118888.1, NM_001147.2 |
| UniProt ID(s) | O15123 |
| UniGene ID(s) | Hs.583870 |
| HGNC ID(s) | HGNC:485 |
| COSMIC ID Link(s) | ANGPT2 |
| KEGG Gene ID(s) | hsa:285 |
| PharmGKB ID(s) | PA24792 |
| General Description of Recombinant Human Angiopoietin-2 / ANG2 Protein. | |
| Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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