PDF DatasheetMouse Angiopoietin-2 / ANG2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Angiopoietin-2 / ANG2 based upon sequence from: Mouse
Host: QP8884 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Angiopoietin-2 / ANG2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8884.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Tyr19 – Ser483
Amino Acid Sequence: YSNFRKSVDS TGRRQYQVQN GPCSYTFLLP ETDSCRSSSS PYMSNAVQRD APLDYDDSVQ RLQVLENILE NNTQWLMKLE NYIQDNMKKE MVEIQQNVVQ NQTAVMIEIG TSLLNQTAAQ TRKLTDVEAQ VLNQTTRLEL QLLQHSISTN KLEKQILDQT SEINKLQNKN SFLEQKVLDM EGKHSEQLQS MKEQKDELQV LVSKQSSVID ELEKKLVTAT VNNSLLQKQQ HDLMETVNSL LTMMSSPNSK SSVAIRKEEQ TTFRDCAEIF KSGLTTSGIY TLTFPNSTEE IKAYCDMDVG GGGWTVIQHR EDGSVDFQRT WKEYKEGFGS PLGEYWLGNE FVSQLTGQHR YVLKIQLKDW EGNEAHSLYD HFYLAGEESN YRIHLTGLTG TAGKISSISQ PGSDFSTKDS DNDKCICKCS QMLSGGWWFD ACGPSNLNGQ YYPQKQNTNK FNGIKWYYWK GSGYS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Angiopoietin-2 / ANG2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Angiopoietin-2 / ANG2 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Angpt2 |
| Entrez Gene ID | 11601 |
| Ensemble Gene ID | ENSMUSG00000031465 |
| RefSeq Protein Accession(s) | NP_031452.2 |
| RefSeq mRNA Accession(s) | NM_007426.4 |
| UniProt ID(s) | O35608 |
| UniGene ID(s) | Mm.439874 |
| COSMIC ID Link(s) | Angpt2 |
| KEGG Gene ID(s) | mmu:11601 |
| General Description of Recombinant Mouse Angiopoietin-2 / ANG2 Protein. | |
| Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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