PDF DatasheetHuman IGF-2 / IGF-II Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant IGF-2 / IGF-II based upon sequence from: Human
Host: QP8601 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) IGF-2 / IGF-II, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8601.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Glu30 – Lys180
Amino Acid Sequence: ETLCGGELVD TLQFVCGDRG FYFSRPASRV SRRSRGIVEE CCFRSCDLAL LETYCATPAK SERDVSTPPT VLPDNFPRYP VGKFFQYDTW KQSTQRLRRG LPALLRARRG HVLAKELEAF REAKRHRPLI ALPTQDPAHG GAPPEMASNR K
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IGF-2 / IGF-II Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IGF-2 / IGF-II Protein General Information | |
|---|---|
| Alternate Names | |
| IGF-2; IGF-II; IGF-II; C11orf43; GRDF; PP9974 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IGF2 |
| Entrez Gene ID | 3481 |
| Ensemble Gene ID | ENSG00000167244 |
| RefSeq Protein Accession(s) | NP_000603.1 |
| RefSeq mRNA Accession(s) | NM_000612.5, NM_001007139.5, NM_001127598.2, NM_001291861.2, NM_001291862.2 |
| UniProt ID(s) | P01344 |
| UniGene ID(s) | Hs.272259 |
| HGNC ID(s) | HGNC:5466 |
| COSMIC ID Link(s) | IGF2 |
| KEGG Gene ID(s) | hsa:3481 |
| PharmGKB ID(s) | PA29699 |
| General Description of Recombinant Human IGF-2 / IGF-II Protein. | |
| The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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