PDF DatasheetHuman IFNAR2 / IFNABR Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant IFNAR2 / IFNABR based upon sequence from: Human
Host: QP8715 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) IFNAR2 / IFNABR, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8715.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ile27 – Ala242
Amino Acid Sequence: ISYDSPDYTD ESCTFKISLR NFRSILSWEL KNHSIVPTHY TLLYTIMSKP EDLKVVKNCA NTTRSFCDLT DEWRSTHEAY VTVLEGFSGN TTLFSCSHNF WLAIDMSFEP PEFEIVGFTN HINVMVKFPS IVEEELQFDL SLVIEEQSEG IVKKHKPEIK GNMSGNFTYI IDKLIPNTNY CVSVYLEHSD EQAVIKSPLK CTLLPPGQES ESAESA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IFNAR2 / IFNABR Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IFNAR2 / IFNABR Protein (27-242aa) General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IFNAR2 |
| Entrez Gene ID | 3455 |
| Ensemble Gene ID | ENSG00000159110 |
| RefSeq Protein Accession(s) | NP_000865.2 |
| RefSeq mRNA Accession(s) | NM_000874.4, NM_001289125.1, NM_001289126.1, NM_001289128.1, NM_207584.2, NM_207585.2 |
| UniProt ID(s) | P48551 |
| UniGene ID(s) | Hs.708195 |
| HGNC ID(s) | HGNC:5433 |
| COSMIC ID Link(s) | Ifnar2 |
| KEGG Gene ID(s) | hsa:3455 |
| PharmGKB ID(s) | PA29671 |
| General Description of Recombinant Human IFNAR2 / IFNABR Protein (27-242aa). | |
| Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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