PDF DatasheetHuman Podocalyxin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Podocalyxin based upon sequence from: Human
Host: QP8764 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Podocalyxin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8764.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gln32 – Phe458
Amino Acid Sequence: QNATQTTTDS SNKTAPTPAS SVTIMATDTA QQSTVPTSKA NEILASVKAT TLGVSSDSPG TTTLAQQVSG PVNTTVARGG GSGNPTTTIE SPKSTKSADT TTVATSTATA KPNTTSSQNG AEDTTNSGGK SSHSVTTDLT STKAEHLTTP HPTSPLSPRQ PTSTHPVATP TSSGHDHLMK ISSSSSTVAI PGYTFTSPGM TTTLLETVFH HVSQAGLELL TSGDLPTLAS QSAGITASSV ISQRTQQTSS QMPASSTAPS SQETVQPTSP ATALRTPTLP ETMSSSPTAA STTHRYPKTP SPTVAHESNW AKCEDLETQT QSEKQLVLNL TGNTLCAGGA SDEKLISLIC RAVKATFNPA QDKCGIRLAS VPGSQTVVVK EITIHTKLPA KDVYERLKDK WDELKEAGVS DMKLGDQGPP EEAEDRF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Podocalyxin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Podocalyxin Protein General Information | |
|---|---|
| Alternate Names | |
| Podocalyxin; PCLP; PCLP-1; Gp200; PC | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PODXL |
| Entrez Gene ID | 5420 |
| Ensemble Gene ID | ENSG00000128567 |
| RefSeq Protein Accession(s) | NP_001018121.1 |
| RefSeq mRNA Accession(s) | NM_001018111.2, NM_005397.3 |
| UniProt ID(s) | O00592 |
| UniGene ID(s) | Hs.744213 |
| HGNC ID(s) | HGNC:9171 |
| COSMIC ID Link(s) | PODXL |
| KEGG Gene ID(s) | hsa:5420 |
| PharmGKB ID(s) | PA33493 |
| General Description of Recombinant Human Podocalyxin Protein. | |
| Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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